Michigan Genetics Resource Center

A patient with cancer who does not meet testing criteria based on cancer features should undergo risk evaluation based on family history.

Check all that apply.

Ashkenazi Jewish ancestry and a 1st or 2nd degree relative diagnosed with breast cancer

Ashkenazi Jewish ancestry and a 1st degree relative with prostate cancer

1st or 2nd degree relative diagnosed with breast cancer ≤50y

A 1st or 2nd degree relative with triple negative breast cancer (ER-, PR-, HER2-)

1st or 2nd degree relative diagnosed with male breast cancer

A 1st or 2nd degree relative with more than one primary breast cancer (synchronous or metachronous)

A 1st or 2nd degree relative with lobular breast cancer, and a family history of diffuse gastric cancer

A 1st or 2nd degree relative with epithelial ovarian cancer (including fallopian tube cancer or peritoneal cancer)

A 1st degree relative with exocrine pancreatic cancer

A 1st degree relative with metastatic or high- or very-high-risk group prostate cancer

A 1st or 2nd degree relative with breast cancer, and a 1st, 2nd or 3rd-degree relative on the same side of the family with ANY: breast cancer diagnosed ≤50y, male breast cancer, ovarian cancer, pancreatic cancer, or prostate cancer with metastatic or high- or very-high-risk group

A 1st degree relative with prostate cancer, and a 1st, 2nd or 3rd-degree relative on the same side of the family diagnosed with ANY: breast cancer at age ≤50y, triple-negative breast cancer, male breast cancer, ovarian cancer, pancreatic cancer, OR metastatic, high- or very-high-risk group prostate cancer

Three or more 1st, 2nd or 3rd-degree relatives on the same side of the family with either breast or prostate cancer (any grade)

A 1st degree relative diagnosed with colorectal cancer <50 y

A 1st degree relative diagnosed with endometrial cancer <50y

A 1st degree relative diagnosed with a colorectal or endometrial cancer and a LS-related cancer (colorectal, endometrial, ovarian, pancreatic, gastric, urothelial, brain, biliary tract, and small intestine cancers, sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas) at any age

Two or more 1st or 2nd degree relatives on the same side of the family with LS-related cancers, with at least 1 of those relatives diagnosed <50y

Three or more 1st or 2nd degree relatives on the same side of the family diagnosed with LS-related cancers at any age

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